Gram Vikas adopted varied and targeted efforts to enable marginalised communities to tackle health, livelihoods, food, education, and mental health issues because of the second wave of the pandemic. We undertook large scale awareness programmes, established quarantine and care facilities, and accelerated vaccination drives. Dry ration kits, a COVID Care Centre, a 24×7 helpline, and a mobile vaccination unit at the destination sites offered comprehensive support to the villagers, the migrant workers, and their families. We mobilised and trained community volunteers, frontline health workers, and local government representatives in COVID-19 response planning, care and surveillance. Technology-equipped learning centres made continued education possible, while recreational games minimised the psychosocial impact of the pandemic on children.